COGS 169: Genetic Information for Behavior: From Single Cells to Mammals (Winter 2017)


MWF 9:00 -9:50am
AP&M 1882

Course website: http://thiscourse.com/ucsd/cogs169/wi17/

Instructors

Ralph Greenspan (Professor)

/ phone: 822-7657

http://greenspanlab.ucsd.edu/index.html

Office Hours: By appointment in AP&M 1862

Course Description

Behavior draws on a wide range of genes acting as a complex source of information. Model organisms -– bacteria, Paramecium, C. elegans, Drosophila, and mice -– have provided insight into how genes influence both innate and learned behaviors, and provide relevant lessons for humans.

Readings

Greenspan, R. and Petit, C., ed. (2013) Neurogenetics.  Current Opinion in Neurobiology, Feb, vol. 23, no. 1. (collection of relevant essays in the field, several of which are indicated below as readings)


For those wishing to have some background material on genetics and molecular biology, you can consult the following files:
Basic genetics and molecular biology

Course Details and Policies

WHEN YOU CLICK ON A LINK TO A READING IN THE SYLLABUS, BE SURE TO CLICK THE "DOWNLOAD THIS FILE" LINK. Ignore the  error message.

Readings, both required and suggested, are indicated below in the Schedule, most of which are taken from the books and journal listed above.

THE MIDTERM EXAM ON FRIDAY FEB. 10 WILL COVER MATERIAL THROUGH THE FEB. 3 LECTURE ON CIRCADIAN RHYTHMS IN CYANOBACTERIA.  THE LINK IN THE "NOTES" BOX FOR THE MIDTERM EXAM CLASS IS A LINK TO SOME PRACTICE QUESTIONS.

I leave the process of getting the answers to you, as a good strategy for studying for the exam.

TERM PAPER OR FINAL EXAM

You have option of either taking a final exam or writing a term paper.  If you opt for a term paper, you need to come see me by Friday Feb. 17, where you and I will discuss possible topics. These can be anything that has come up in class, as long as it has a major genetic component.  Once you have a topic, you will be required to prepare an outline of the paper, which will be due on Feb. 27.  The paper itself (maximum of 5 pages) is due on March 17, the date of the last class.  The final exam is on March 22, 8am-11am.  The final will cover all of the topics dealt with in the course.

Course Schedule

Week Date Topic Readings (required) Suggested Reading Notes
1 Mon Jan 09 Bacterial chemotaxis Adler Sci Am Non-genetic individuality Lecture 1 Bacterial chemotaxis
Wed Jan 11 Paramecium  Paramecium Behavior genetics Paramecium Calcium channels Lecture 2 Paramecium
Fri Jan 13 Fly Communication (guest lecturer,      
J-F. Ferveur, CNRS, Dijon)
PNAS-2012-Bousquet Ferveur_BEGEOS Lecture 3 -- JF Chemical communication
2 Wed Jan 18 Social behavior (worms) Varieties of behavioral natural variation Aggregation Lecture 4 Worm behavior
Fri Jan 20 Receptor natural variants (worm) Foraging behavior
Lecture 5 -- Worm variants
3 Mon Jan 23 Courtship (Drosophila) I Love on the Fly Courtship connectome Lecture 6 -- Courtship I
Wed Jan 25 Courtship (Drosophila) II Courtship organization
Lecture 7 -- Courtship II
Fri Jan 27 Fly circadian rhythms I Internal wakeup call
Lecture 8 -- Fly rhythms I
4 Mon Jan 30 Fly circadian rhythms II Fly circadian rhythms and sleep
Lecture 9 -- Fly rhythms II
Wed Feb 01 Cyanobacterial circadian rhythms I Cyanobacterial circadian rhythms
Lecture 10: The Cyanobacterial Clock
Fri Feb 03 Cyanobacterial circadian rhythms II Cyanobacterial circadian rhythms review
Lecture 11: The Cyanobacterial Clock II
5 Mon Feb 06 Fly sleep I Fly circadian rhythms and sleep
Lecture 12: Sleep I
Wed Feb 08 Fly sleep II Fly sleep
Lecture 13: Sleep II
Fri Feb 10 MIDTERM

COGS Final. Pactice answers
6 Mon Feb 13 Addiction (guest lecture, 
J-P. Changeux,
College de France)
JPC article molpsych2012, J-P. Lecture 14: Addiction -- mice
Wed Feb 15 Fly addiction/sensitization (guest lecture, R. Andretic) Heberlein_DrosAddicModel_HumGen2012 Rozi- Abarca_PNAS02 Lecture 15: Fly addiction & sensitization
Fri Feb 17 Fly social and anti-social behavior Fly social behavior Fly recognition Lecture 16 Anti-social flies
7 Wed Feb 22 Natural variants -- selection Varieties of selection experience Dierick & Greenspan NG. Lecture 17: Natural variants
Fri Feb 24 Selection  Toma et al., 2002
Lecture 18: Selection
8 Mon Feb 27 Fly learning & memory Fly memory The World As We Find It Lecture 19: Learning and Memory
Wed Mar 01 Social behavior -- mammals Social attachment Pair bonding Lecture 20: Mammalian Social Behavior
Fri Mar 03 Psychiatric Genetics I Personality genetics Autism Lecture 21: Psychiatric 
9 Mon Mar 06 Psychiatric Genetics II Schizophrenia
Lecture 22: Psychiatric 
Wed Mar 08 Visual learning/attention 
(guest lecture,
D. Grover)
Attention review Visual selection Lecture 23: Selective Attention in Insects
Fri Mar 10
Genetics of anatomical connectome
Anatomical connectome Worm connectome Lecture 24: Connectome
10 Mon Mar 13
Anxiety and fear, (guest lecture,
A. Palmer, UCSD)
QTL Mapping EtOH and drug QTLs Lecture 25: Genetics of Fear and Anxiety
Wed Mar 15 Brain and cognitive development
(guest lecture, 
T. Jernigan, UCSD)
Genetic Foundation of Human Intelligence GWAS Cognition Lecture 26: Genetics of General Cognitive Ability
Fri Mar 17 Genetics of functional connectome BRAIN Iniative
Lecture 27: Genetics of Functional Connectome
12 Tue Mar 28


Final exam answers